| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| Brough Douglas E Chief Scientific Officer | D | Common Stock | |||||
| Brough Douglas E Chief Scientific Officer | M | Common Stock | |||||
| Brough Douglas E Chief Scientific Officer | M | Stock Options (right to buy) | |||||
| Butman Bryan T Senior Vice President | D | Common Stock | |||||
| Butman Bryan T Senior Vice President | M | Common Stock |