| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| Biotechnology Value Fund L P | J | Common Stock, par value $0.002 | |||||
| Bvf Partners L P/Il | J | Common Stock, par value $0.002 | |||||
| Bvf Inc/Il | J | Common Stock, par value $0.002 | |||||
| Biotechnology Value Fund II LP | J | Common Stock, par value $0.002 | |||||
| Bvf Investments LLC | J | Common Stock, par value $0.002 |