Polaryx Therapeutics Inc. – Material Contracts Watch

from 8-K 8 pages Stock Purchase Agreement

from 10-K 1 page Addendum #2 to Consultancy Agreement

from S-1/A 14 pages Indemnification Agreement

from S-1/A 20 pages Polaryx Therapeutics, Inc. 2025 Equity Incentive Plan

from S-1 2 pages May 31, 2023 Mstone Partners Healthcare Limited (“Mstone”) Unit 312, 3/F Great Eagle Centre 23 Harbour Road, Wanchai Hong Kong Re: Letter Agreement, Dated November 30, 2021, by and Between Mstone and Polaryx Therapeutics, Inc. (The “Services Agreement”) May 31, 2023 Page | 2 We Appreciate Mstone’s Contributions to the Company’s Development and Success. Very Truly Yours, Polaryx Therapeutics, Inc. By: /S/ Andrew O Name: Andrew O Title: Director Accepted and Agreed: Mstone Partners Healthcare Limited By: /S/ Alex Keun Mo Yang Name: Alex Keun Mo Yang Title: Director

from S-1 1 page Addendum to Consultancy Agreement

from S-1 8 pages Mstone Partners Healthcare Limited (“Mstone”) Unit 312, 3/F Great Eagle Centre 23 Harbour Road, Wanchai Hong Kong November 30, 2021 1. Services. 1.1 the Company Hereby Engages Mstone, and Mstone Hereby Accepts Such Engagement, as an Independent Contractor to Provide Certain Services to the Company on the Terms and Conditions Set Forth in This Agreement. 1.2 Mstone Shall Provide to the Company the Services Set Forth in Schedule 1 (The “Services”). 1.3 the Company Shall Not Control the Manner or Means by Which Mstone or Mstone Employees or Contractors Perform the Services, Including but Not Limited to the Time and Place Mstone Performs the Services

from S-1 7 pages Confidential Master Services Agreement

from S-1 3 pages Novation Agreement

from S-1 16 pages License Agreement Between Rush University Medical Center and Somaryx Therapeutics Limited

from S-1 14 pages 1. Backround

from S-1 19 pages Polaryx Therapeutics, Inc. 2025 Equity Incentive Plan

from S-1 4 pages Lisa Bollinger September 29, 2025

from S-1 4 pages G. Michael Landis October 26, 2025

from S-1 7 pages Polaryx Therapeutics, Inc. 2022 Equity Incentive Plan Grant Notice for Restricted Stock Unit Award

from S-1 19 pages Polaryx Therapeutics, Inc. 2022 Equity Incentive Plan

from DRS/A 2 pages May 31, 2023 Mstone Partners Healthcare Limited (“Mstone”) Unit 312, 3/F Great Eagle Centre 23 Harbour Road, Wanchai Hong Kong Re: Letter Agreement, Dated November 30, 2021, by and Between Mstone and Polaryx Therapeutics, Inc. (The “Services Agreement”) May 31, 2023 Page | 2 We Appreciate Mstone’s Contributions to the Company’s Development and Success. Very Truly Yours, Polaryx Therapeutics, Inc. By: /S/ Andrew O Name: Andrew O Title: Director Accepted and Agreed: Mstone Partners Healthcare Limited By: /S/ Alex Keun Mo Yang Name: Alex Keun Mo Yang Title: Director

from DRS/A 1 page Addendum to Consultancy Agreement

from DRS/A 9 pages Mstone Partners Healthcare Limited (“Mstone”) Unit 312, 3/F Great Eagle Centre 23 Harbour Road, Wanchai Hong Kong November 30, 2021 1. Services. 1.1 the Company Hereby Engages Mstone, and Mstone Hereby Accepts Such Engagement, as an Independent Contractor to Provide Certain Services to the Company on the Terms and Conditions Set Forth in This Agreement. 1.2 Mstone Shall Provide to the Company the Services Set Forth in Schedule 1 (The “Services”). 1.3 the Company Shall Not Control the Manner or Means by Which Mstone or Mstone Employees or Contractors Perform the Services, Including but Not Limited to the Time and Place Mstone Performs the Services