| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| RA Capital Healthcare Fund LP | A | Stock Option (Right to Buy) | |||||
| Ra Capital Management, L.P. | A | Stock Option (Right to Buy) | |||||
| Kolchinsky Peter | A | Stock Option (Right to Buy) | |||||
| Shah Rajeev M. | A | Stock Option (Right to Buy) | |||||
| Detheux Michel | A | Stock option (right to buy) |