| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| Fox Jonathan C | A | Common Stock | |||||
| Donovan Joanne M. CMO | S | Common Stock | |||||
| Russell Alan J Chief Scientific Officer | A | Stock Option (Right to Buy) | |||||
| Russell Alan J Chief Scientific Officer | A | Restricted Stock Units | |||||
| Russell Alan J Chief Scientific Officer | A | Stock Option (Right to Buy) |