Spero Therapeutics Inc. – Material Contracts Watch

from 10-Q 5 pages Termination Agreement

from 10-Q 15 pages Executive Employment Agreement

from 10-Q 34 pages Certain Identified Information Has Been Excluded From the Exhibit by Marking Such Portions With Brackets (“[***]”) Because It Is Both (I) Not Material and (II) Is the Type of Information That the Registrant Treats as Private or Confidential. Limited Recourse Guaranty

from 10-Q 73 pages Certain Identified Information Has Been Excluded From the Exhibit by Marking Such Portions With Brackets (“[***]”) Because It Is Both (I) Not Material and (II) Is the Type of Information That the Registrant Treats as Private or Confidential

from 10-Q 103 pages Certain Identified Information Has Been Excluded From the Exhibit by Marking Such Portions With Brackets (“[***]”) Because It Is Both (I) Not Material and (II) Is the Type of Information That the Registrant Treats as Private or Confidential

from 10-Q 99 pages Certain Identified Information Has Been Excluded From the Exhibit by Marking Such Portions With Brackets (“[***]”) Because It Is Both (I) Not Material and (II) Is the Type of Information That the Registrant Treats as Private or Confidential. Collaboration and License Agreement by and Among Spero Therapeutics, Inc., Innovent Biologics (Suzhou) Co., Ltd., and Fortvita Biologics (USA), Inc. Dated as of July 8, 2026

from 10-Q 9 pages Spero Therapeutics, Inc. Restricted Stock Unit Agreement – Incorporated Terms and Conditions

from 10-Q 8 pages Spero Therapeutics, Inc. Stock Option Agreement – Incorporated Terms and Conditions

from 10-K 4 pages December 31, 2025 Spero Therapeutics, Inc. 675 Massachusetts Avenue, 14thfloor Cambridge, Massachusetts 02139 Re: Termination of License Agreement Ladies and Gentlemen

from 10-Q 15 pages Spero Therapeutics, Inc. Amended and Restated 2017 Stock Incentive Plan (As Amended on June 12, 2025) 1. Definitions. Unless Otherwise Specified or Unless the Context Otherwise Requires, the Following Terms, as Used in This Spero Therapeutics, Inc. 2017 Stock Incentive Plan, Have the Following Meanings: Administrator Means the Board of Directors, Unless It Has Delegated Power to Act on Its Behalf to the Committee, in Which Case the Term Administrator Means the Committee. Affiliate Means a Corporation or Other Entity Which, for Purposes of Section 424 of the Code, Is a Parent or Subsidiary of the Company, Direct or Indirect. Agreement Means a Written or Electronic Document Setting Forth the Terms of a Stock Right Delivered Pursuant to the Plan, in Such Form as the Administrator Shall Approve. Board of Directors Means the Board of Directors of the Company

from 10-Q 17 pages Amended and Restated Executive Employment Agreement

from 10-Q 13 pages April 28, 2025 Mr. Satyavrat Shukla 125 Lyman Road Milton, Ma 02186 Dear Mr. Shukla

from 10-K 4 pages Amendment 2 to Exclusive License Agreement

from 10-K 4 pages Amendment 1 to Exclusive License Agreement

from 10-K 10 pages Amended & Restated Consulting Agreement

from 10-K 10 pages Consulting Agreement

from 10-K 8 pages Material contract

from 10-K 6 pages Material contract

from 10-K 6 pages Material contract

from 10-K 6 pages Material contract