Spruce Biosciences Inc – Credit Agreements Watch

from 8-K 21 pages Certain Identified Information Has Been Excluded From This Exhibit Because It Is Both Not Material and Is the Type That the Registrant Treats as Private or Confidential. Information That Was Omitted Has Been Noted in This Document With a Placeholder Identified by the Mark “[***]”. Supplement to the Loan and Security Agreement Dated as of January 7, 2026 Among Spruce Biosciences, Inc. (“Borrower”) and Avenue Capital Management II, L.P., a Delaware Limited Partnership, as Administrative Agent and Collateral Agent (In Such Capacity “Agent”) and Avenue Venture Opportunities Fund, L.P. II, a Delaware Limited Partnership (“Avenue 2”), as a Lender and Any Person From Time to Time Party Hereto as a Lender

from 8-K 37 pages Certain Identified Information Has Been Excluded From This Exhibit Because It Is Both Not Material and Is the Type That the Registrant Treats as Private or Confidential. Information That Was Omitted Has Been Noted in This Document With a Placeholder Identified by the Mark “[***]”. Loan and Security Agreement Dated as of January 7, 2026 Among Spruce Biosciences, Inc. a Delaware Corporation, as “Borrower”, and Avenue Capital Management II, L.P., a Delaware Limited Partnership (As Administrative Agent and Collateral Agent (In Such Capacity “Agent”) and Avenue Venture Opportunities Fund II, L.P., a Delaware Limited Partnership, (“Avenue 2”) as a Lender and Any Person From Time to Time Party Hereto as a Lender (In Such Capacity, With Avenue 2, a “Lender” and Collectively, the “Lenders”) Loan and Security Agreement

from 10-Q 9 pages Certain Identified Information Has Been Excluded From This Exhibit Because It Is Both Not Material and Is the Type That the Registrant Treats as Private or Confidential. Information That Was Omitted Has Been Noted in This Document With a Placeholder Identified by the Mark “[***]”. Second Amendment to Loan and Security Agreement

from 10-K 10 pages First Amendment to Loan and Security Agreement

from S-1 6 pages Deferral Agreement Effective Date: April 2, 2020 Loan Agreement Date (Use Restated Date if Applicable): September 23, 2019 Borrower: Spruce Biosciences, Inc. ☐ if This Box Is Checked, Additional Borrowers (“Additional Borrowers”) Are Listed in the Annex Attached Hereto (Borrower and Such Additional Borrowers, Collectively, “Borrower”). Loan Agreement: That Certain Loan and Security Agreement, Dated as of the Loan Agreement Date, Between Borrower, Additional Borrowers, if Any, and Silicon Valley Bank (“Bank”), as Amended, Restated or Otherwise Modified and in Effect From Time to Time. Guarantor(s) or Pledgor(s): ☐ if This Box Is Checked, the Obligations of Borrower Are Guaranteed or Secured by a Pledge of Assets and the Consent and Ratification Attached Hereto Shall Apply and Must Be Completed for Each Guarantor and/or Pledgor

from S-1 45 pages Loan and Security Agreement

from DRS 6 pages Deferral Agreement Effective Date: April 2, 2020 Loan Agreement Date (Use Restated Date if Applicable): September 23, 2019 Borrower: Spruce Biosciences, Inc. ☐ if This Box Is Checked, Additional Borrowers (“Additional Borrowers”) Are Listed in the Annex Attached Hereto (Borrower and Such Additional Borrowers, Collectively, “Borrower”). Loan Agreement: That Certain Loan and Security Agreement, Dated as of the Loan Agreement Date, Between Borrower, Additional Borrowers, if Any, and Silicon Valley Bank (“Bank”), as Amended, Restated or Otherwise Modified and in Effect From Time to Time. Guarantor(s) or Pledgor(s): ☐ if This Box Is Checked, the Obligations of Borrower Are Guaranteed or Secured by a Pledge of Assets and the Consent and Ratification Attached Hereto Shall Apply and Must Be Completed for Each Guarantor and/or Pledgor

from DRS 45 pages Loan and Security Agreement