| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| Smith Jason Drew General Counsel | S | Ordinary Shares | |||||
| Schoenberg Mark Chief Medical Officer | S | Ordinary Shares | |||||
| Barrett Elizabeth A. Chief Executive Officer | A | Restricted Stock Units | |||||
| Smith Jason Drew General Counsel | A | Restricted Stock Units | |||||
| Smith Jason Drew General Counsel | M | Ordinary Shares |