Akcea Therapeutics, Inc. – Indentures Watch

from 10-K 4 pages Description of Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934, as Amended Description of Capital Stock

from S-3ASR 15 pages Akcea Therapeutics, Inc. Form of Debt Securities Warrant Agreement

from S-3ASR 17 pages Akcea Therapeutics, Inc. Form of Preferred Stock Warrant Agreement

from S-3ASR 21 pages Akcea Therapeutics, Inc. and , as Warrant Agent Form of Common Stock Warrant Agreement Dated as of Akcea Therapeutics, Inc. Form of Common Stock Warrant Agreement

from S-3ASR 55 pages Akcea Therapeutics, Inc., Issuer and [Trustee], Trustee Indenture Dated as of [·], 20__ Debt Securities

from DEFA14A 21 pages Akcea Therapeutics, Inc. Amended and Restated Investor Rights Agreement March 14, 2018 Akcea Therapeutics, Inc. Amended and Restated Investor Rights Agreement

from 8-K 21 pages Akcea Therapeutics, Inc. Amended and Restated Investor Rights Agreement March 14, 2018 Akcea Therapeutics, Inc. Amended and Restated Investor Rights Agreement

from S-1/A ~5 pages 001 This Certifies That Is the Owner of Akcea Therapeutics, Inc. Incorporated Under the Laws of the State of Delaware Authorized: 110,000,000 Common Shares, $0.001 Par Value Per Share Fully Paid and Non-Assessable Common Stock, $0.001 Par Value of Akcea Therapeutics, Inc. Cusip 00972l 10 7 See Reverse for Certain Definitions Countersigned: American Stock Transfer & Trust Company, LLC 6201 15th Avenue Brooklyn, Ny 11219 by Transfer Agent and Registrar Authorized Officer in Witness Whereof, the Corporation Has Caused This Certificate to Be Signed by the Facsimile Signatures of Its Duly Authorized Officers and to Be Sealed With the Facsimile Seal of the Corporation. Dated: President and Chief Executive Officerchief Operating Officer Akcea Therapeutics, Inc. American Stock Transfer & Trust Company, LLC Transfer Fee: As Required

from S-1 24 pages Akcea Therapeutics, Inc. Investor Rights Agreement December 18, 2015 Ackea Therapeutics, Inc. Investor Rights Agreement