Zynerba Pharmaceuticals Inc – Indentures Watch

from S-3 51 pages Zynerba Pharmaceuticals, Inc. and , as Trustee Indenture Dated as of ,

from 10-K 2 pages Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

from 10-K 2 pages Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

from S-3 51 pages Zynerba Pharmaceuticals, Inc. and , as Trustee Indenture Dated as of ,

from S-3 51 pages Zynerba Pharmaceuticals, Inc. and , as Trustee Indenture Dated as of ,

from S-3 37 pages Zynerba Pharmaceuticals, Inc. and , as Trustee Indenture Dated as of ,

from S-1/A 1 page Zp Incorporated Under the Laws of the State of Delaware Cusip 98986x 10 9 See Reverse for Certain Definitions This Certifies That Is the Owner of Fully Paid and Nonassessable Shares of Common Stock, $0.001 Par Value Per Share, of Zynerba Pharmaceuticals, Inc. Transferable on the Books of the Corporation in Person or by Its Duly Authorized Attorney Upon Surrender of This Certificate Properly Endorsed. This Certificate Is Not Valid Unless Countersigned by the Transfer Agent and Registered by the Registrar. Witness the Facsimile Signatures of the Corporation’s Duly Authorized Officers. Dated Chairman and Chief Executive Officer Treasurer Countersigned and Registered: American Stock Transfer & Trust Company, LLC and Registrar By: (Brooklyn, Ny) Transfer Agent Authorized Signature

from S-1 28 pages Zynerba Pharmaceuticals, Inc. Third Amended and Restated Stockholders Agreement

from DRS 28 pages Zynerba Pharmaceuticals, Inc. Third Amended and Restated Stockholders Agreement