| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| Vivo Ventures v Affiliates Fund, L.P. | U | Common Stock | |||||
| Vivo Ventures Fund V, L.P. | U | Common Stock | |||||
| Vivo Ventures V, LLC | U | Common Stock | |||||
| Singer Jonathon M EVP and CFO | D | Common Stock | |||||
| Singer Jonathon M EVP and CFO | D | Stock Option to Buy |