| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| BB Biotech AG Bearer Shares | S | Common Stock | |||||
| Biotech Target N V | S | Common Stock | |||||
| Lalande Kevin M. | A | Stock Option (right to buy) | |||||
| Gruia Gabriela | A | Stock Option (right to buy) | |||||
| Selick Harold E | A | Stock Option (right to buy) |