EPIRUS Biopharmaceuticals, Inc. – Credit Agreements – BamSEC

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from 10-K 4 pages Consent and First Loan Modification Agreement

from 8-K 47 pages Loan and Security Agreement

from 8-K ~5 pages Confidential Loan Proposal For: Combinatorx, Incorporated Submitted By: William B. Stickle Combinatorx, Incorporated Mr. Justin A. Renz Vice President, Finance and Treasurer Combinatorx, Incorporated 245 First Street, 16th Floor Cambridge, Ma 02142 Dear Mr. Renz

from 8-K 2 pages Ge Capital Ge Capital Services Pte Ltd 6 Temasek Boulevard #35-01 Suntec Tower Four Singapore 038986 T +65 6226 3822 F +65 6222 3681 Co. No. 199307961g 23 January 2007 Combinatorx (Singapore) Pte. Ltd. 11 Biopolis Way Helios #08-05 Singapore 138667 Attn : Mr. Ralf Marius Altmeyer Director Dear Sir, Term Loan Facility Schedule Number 001 and 002 Forming a Part of the Letter of Offer Dated 20 November 2006. Schedule Number 001